Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 16/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064294 | 1.00 | TACR1 (0.54) | TACR1RIPK1GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL6550098 | 0.99 | TACR1 (0.53) | TACR1RIPK1GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL5218238 | 0.88 | TACR1 (0.53) | TACR1RIPK1GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL30145299 | 0.86 | TACR1 (0.52) | TACR1RIPK1GRM5HSP90AA1HSP90AB1 | |
| SCHEMBL5414345 | 0.84 | TACR1 (0.44) | TACR1 | |
| SCHEMBL29892075 | 0.83 | AGTR2 (0.47) | RIPK1 | |
| SCHEMBL5411632 | 0.83 | TACR1 (0.58) | TACR1 | |
| SCHEMBL5409127 | 0.83 | TACR1 (0.53) | TACR1 | |
| SCHEMBL6800492 | 0.83 | TACR1 (0.53) | TACR1 | |
| Maleic Acid SCHEMBL30145281 | 0.82 | TACR1 (0.47) | TACR1RIPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653956-A1 | COMBINATIONS OF PAROXETINE AND 4-(S)-(4-ACETYL-PIPERAZIN-1-YL)-2-(R)-(4-FLUORO-2-METHYL-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID ¬1-(R)-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL|METHYLAMIDE FOR TREATMENT OF DEPRESSION AND/OR ANXIETY. | GLAXO GROUP LIMITED (GB) | 2006-05-10 | — | — | EP | disclosed |
| WO-2004091616-A1 | COMBINATIONS OF PAROXETINE AND 4- (S) - (4-ACETYL-PIPERAZIN-1-YL) -2- (R)- (4-FLUORO-2-METHYL-PHENYL -PIPERIDINE-1-CARBOXYLIC ACID [1- (R) -(3,5-BIS-TRIFLUOROMETHYL-PHENYL) -ETHYL] METHYLAMIDE FOR TREATMENT OF DEPRESSION AND / OR ANXIETY | GLAXO GROUP LIMITED (GB) | 2004-10-28 | — | — | WO | disclosed |