Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027236 | 0.88 | PIK3C3 (0.42) | IRAK4PIK3C3TGFBR1AAK1GSK3B | |
| SCHEMBL7026492 | 0.85 | TGFBR1 (0.41) | IRAK4PIK3C3TGFBR1AAK1GSK3B | |
| SCHEMBL7020508 | 0.82 | TGFBR1 (0.40) | RIPK3IRAK4PIK3C3TGFBR1AAK1 | |
| SCHEMBL29402022 | 0.81 | ATR (0.46) | RIPK3IRAK4PIK3C3TGFBR1GSK3B | |
| SCHEMBL2029613 | 0.81 | ATR (0.46) | RIPK3IRAK4PIK3C3TGFBR1GSK3B | |
| SCHEMBL6992479 | 0.79 | IRAK4 (0.42) | RIPK3IRAK4PIK3C3TGFBR1AAK1 | |
| SCHEMBL1104982 | 0.78 | RIPK3 (0.44) | RIPK3IRAK4PIK3C3TGFBR1AAK1 | |
| SCHEMBL14694696 | 0.76 | USP30 (0.39) | PIK3C3AAK1 | |
| SCHEMBL5251219 | 0.75 | EGFR (0.57) | IRAK4PIK3C3TGFBR1AAK1GSK3B | |
| SCHEMBL5225197 | 0.75 | TGFBR1 (0.43) | IRAK4PIK3C3TGFBR1AAK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |
| EP-1364949-A1 | JNK INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 2003-11-26 | — | — | EP | disclosed |