Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MYLK2 | Q9H1R3 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | BMP2K | Q9NSY1 | 2/20 | 0.39 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7026837 | 0.88 | IRAK4 (0.42) | TGFBR1IRAK4AAK1GSK3BDYRK1A | |
| SCHEMBL6992479 | 0.88 | IRAK4 (0.42) | TGFBR1IRAK4AAK1NR3C2CYP3A4 | |
| SCHEMBL6990608 | 0.87 | AAK1 (0.41) | TGFBR1IRAK4AAK1NR3C2GSK3B | |
| SCHEMBL7024075 | 0.86 | AAK1 (0.42) | TGFBR1IRAK4AAK1NR3C2CYP3A4 | |
| SCHEMBL7020508 | 0.82 | TGFBR1 (0.40) | TGFBR1IRAK4AAK1GAKROCK2 | |
| SCHEMBL5251219 | 0.78 | EGFR (0.57) | TGFBR1IRAK4AAK1GSK3BDYRK1A | |
| SCHEMBL8670718 | 0.77 | FDPS (0.50) | TGFBR1IRAK4AAK1NR3C2CYP3A4 | |
| SCHEMBL5812808 | 0.75 | RIPK3 (0.41) | TGFBR1IRAK4AAK1GAKROCK2 | |
| SCHEMBL828560 | 0.75 | TP53 (0.51) | — | |
| SCHEMBL29992322 | 0.74 | AAK1 (0.48) | TGFBR1IRAK4AAK1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180518-B1 | 5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2007-01-17 | — | — | EP | disclosed |
| EP-1268474-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| EP-1180518-A1 | 5-PYRIDYL-1,3-AZOLE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-20 | — | — | EP | disclosed |
| WO-2001074811-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | disclosed |