Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | CES2 | O00748 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10350085 | 0.85 | MAPT (0.56) | CES1CES2LMNAMDM2KMT2A | |
| SCHEMBL28279721 | 0.78 | LMNA (0.52) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL28917628 | 0.78 | CES1 (0.52) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL3495542 | 0.77 | PGR (0.47) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL1287117 | 0.77 | PGR (0.47) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL5802193 | 0.77 | ATM (0.50) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL11215012 | 0.77 | TDP1 (0.47) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL27244203 | 0.76 | NPC1 (0.58) | LMNATDP1KMT2AMAPTTSHR | |
| SCHEMBL28457962 | 0.75 | TDP1 (0.55) | CES1CES2LMNAMDM2TDP1 | |
| SCHEMBL8259661 | 0.75 | TACR1 (0.57) | LMNATDP1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |