Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27244159 | 0.86 | LMNA (0.58) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL11613071 | 0.84 | ATM (0.47) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL11619479 | 0.81 | ALDH1A1 (0.49) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL29850235 | 0.79 | ATM (0.50) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL30881459 | 0.78 | GAA (0.55) | ATMGAAL3MBTL1LMNAHPGD | |
| SCHEMBL27244202 | 0.78 | GAA (0.55) | ATMGAAL3MBTL1LMNAHPGD | |
| SCHEMBL5813617 | 0.77 | CES1 (0.52) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL11215012 | 0.75 | TDP1 (0.47) | ATMHSP90AA1GAANPC1RAB9A | |
| SCHEMBL1287117 | 0.75 | PGR (0.47) | ATMHSP90AA1NPC1RAB9ATDP1 | |
| SCHEMBL3495542 | 0.75 | PGR (0.47) | ATMHSP90AA1NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |