Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 11/20 | 0.40 |
| ▸ | RORC | P51449 | 6/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707172 | 0.92 | RORB (0.46) | RORBRORCGRM2 | |
| Tradipitant SCHEMBL29810017 | 0.90 | RORB (0.42) | RORBRORCGRM2TACR1CDC7 | |
| Tradipitant SCHEMBL2898629 | 0.90 | RORB (0.42) | RORBRORCGRM2TACR1CDC7 | |
| SCHEMBL4705482 | 0.87 | RORB (0.41) | RORBRORCGRM2TACR1IDH1 | |
| SCHEMBL4706229 | 0.87 | IDH1 (0.44) | RORBRORCGRM2IDH1GPBAR1 | |
| SCHEMBL4707848 | 0.86 | RORB (0.41) | RORBRORCGRM2TACR1GPBAR1 | |
| SCHEMBL4708282 | 0.85 | RORB (0.40) | RORBRORCGRM2CDC7IDH1 | |
| SCHEMBL5816003 | 0.84 | GRM2 (0.34) | GRM2TACR1CDC7 | |
| SCHEMBL4707594 | 0.84 | RORB (0.43) | RORBRORCGRM2 | |
| SCHEMBL4759328 | 0.83 | RORB (0.43) | RORBRORCTACR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083711-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-10 | — | — | WO | claimed |
| WO-2006083711-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-10 | — | — | WO | disclosed |