Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.37 |
| ▸ | SRC | P12931 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | ABL1 | P00519 | 6/20 | 0.34 |
| ▸ | HCK | P08631 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.34 |
| ▸ | MTOR | P42345 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.34 |
| ▸ | PRKDC | P78527 | 6/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814550 | 0.85 | JAK2 (0.54) | JAK2JAK3JAK1EGFRSRC | |
| SCHEMBL30513350 | 0.85 | JAK2 (0.54) | JAK2JAK3JAK1EGFRSRC | |
| SCHEMBL18642029 | 0.84 | JAK2 (0.46) | JAK2JAK3JAK1EGFRSRC | |
| SCHEMBL1443178 | 0.73 | ADK (0.47) | SRCKDRABL1MTORCSNK1A1 | |
| SCHEMBL5805110 | 0.73 | RET (0.64) | JAK2JAK3EGFRSRCKDR | |
| SCHEMBL29617723 | 0.73 | RET (0.64) | JAK2JAK3EGFRSRCKDR | |
| SCHEMBL5816791 | 0.71 | NR3C1 (0.46) | JAK2JAK3JAK1 | |
| SCHEMBL5814555 | 0.70 | RET (0.38) | JAK2JAK3JAK1EGFRSRC | |
| SCHEMBL30513264 | 0.69 | EGFR (0.59) | EGFRSRCKDRPIK3CDABL1 | |
| SCHEMBL6688373 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| EP-1212327-B1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | JAK2 1212/4885JAK3 1066/4885JAK1 972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.