Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.64 |
| ▸ | HTR7 | P34969 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10851169 | 0.98 | IDO1 (0.62) | IDO1HTR7KDM4ENLRP3DRD2 | |
| SCHEMBL16264954 | 0.95 | IDO1 (0.66) | IDO1HTR7KDM4ENLRP3DRD2 | |
| SCHEMBL7041168 | 0.88 | IDO1 (0.70) | IDO1HTR7KDM4EDRD2MAPT | |
| SCHEMBL1456203 | 0.84 | IDO1 (0.64) | IDO1HTR7KDM4EDRD2DRD1 | |
| SCHEMBL319056 | 0.82 | IDO1 (0.66) | IDO1HTR7KDM4EDRD2DRD1 | |
| SCHEMBL10248055 | 0.81 | IDO1 (0.60) | IDO1HTR7KDM4EDRD2DRD1 | |
| SCHEMBL2693278 | 0.81 | IDO1 (0.64) | IDO1KDM4EDRD2MAPTGSK3B | |
| SCHEMBL1542794 | 0.79 | IDO1 (0.77) | IDO1HTR7KDM4EHTR2AMAPT | |
| SCHEMBL1455287 | 0.79 | IDO1 (0.54) | IDO1HTR7KDM4EDRD2DRD1 | |
| SCHEMBL2149070 | 0.79 | HTR7 (0.59) | IDO1HTR7DRD2DRD1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304175-A | Preparation method of chiral 3-benzofuran-3-amino-2-oxindole derivative | 浙江理工大学 | 2023-12-29 | — | — | CN | disclosed |
| US-9718775-B2 | Oxindole compounds and compositions comprising the same | MILLIKEN & COMPANY (US) | 2017-08-01 | — | — | US | disclosed |
| CN-106458890-A | Oxindole compounds and compositions comprising the same | 美利肯公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-3116855-A1 | OXINDOLE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | Milliken & Company (US) | 2017-01-18 | — | — | EP | disclosed |
| CN-103380125-B | Prepare the method for the oxindole that triazinyl replaces | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-25 | — | — | CN | disclosed |
| US-20150259287-A1 | OXINDOLE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | MILLIKEN & COMPANY | 2015-09-17 | — | — | US | disclosed |
| WO-2015138067-A1 | OXINDOLE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | MILLIKEN & COMPANY (US) | 2015-09-17 | — | — | WO | disclosed |
| CN-103380125-A | Method for producing triazinyl-substituted oxindoles | BAYER IP GMBH | 2013-10-30 | — | — | CN | disclosed |
| WO-2006082453-A1 | RACEMIC AND OPTICALLY ACTIVE 4-CHLORO-3-(5-CHLORO-3-ALKYL-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)BENZOIC ACID DERIVATIVES AND THE PREPARATION THEREOF | SANOFI-AVENTIS (FR) | 2006-08-10 | — | — | WO | disclosed |
| US-5607959-A | ANALGESICS | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0175551-B1 | ANALGESIC AND ANTIINFLAMMATORY 1,3-DIACYL-2-OXINDOLE COMPOUNDS | PFIZER INC. (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4808601-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1989-02-28 | — | — | US | disclosed |
| US-4752609-A | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1988-06-21 | — | — | US | disclosed |
| US-4690943-A | ENZYME INHIBITOR OF CYCLOOXYGENASE AND LIPOXYGENASE | PFIZER INC. (US) | 1987-09-01 | — | — | US | disclosed |
| US-4665194-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4652658-A | Process for making 2-oxindole-1-carboxamides and intermediates therefor | PFIZER INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0212481-A1 | Indolinone derivatives, processes for their preparation, pharmaceutical compounds containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |
| EP-0175551-A1 | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds | PFIZER INC. (US) | 1986-03-26 | — | — | EP | disclosed |
| US-4569942-A | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents | PFIZER INC. (US) | 1986-02-11 | — | — | US | disclosed |
| US-4021469-A | Process for preparing N-phenylcarbamates | JOHN WYETH & BROTHER LIMITED (EN) | 1977-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259287-A1 | OXINDOLE COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME | AOX1, GPX4, CAT | IDO1 179/4885HTR7 320/4885KDM4E 2912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.