Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6468117 | 1.00 | CA1 (0.50) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL6468108 | 1.00 | CA1 (0.50) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL105898 | 1.00 | CA1 (0.50) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL105897 | 1.00 | CA1 (0.50) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL28714104 | 1.00 | CA1 (0.50) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL10907389 | 0.96 | CA1 (0.48) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL7770470 | 0.96 | CA4 (0.54) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL9689380 | 0.96 | CA1 (0.48) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL9702540 | 0.96 | CA1 (0.48) | CA1CA9CA4FAHD1BBOX1 | |
| Fumaric Acid SCHEMBL9551551 | 0.96 | CA1 (0.48) | CA1CA9CA4FAHD1BBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3511 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260097044-A1 | ION PAIR LIQUID CRYSTAL FORMULATIONS FOR LONG-ACTING INJECTABLES OF POORLY SOLUBLE DRUGS | FORDOZ PHARMA CORP. (US) | 2026-04-09 | — | — | US | claimed |
| EP-4704582-A1 | DEPHOSPHORYLATION OF SKIM MILK, ULTRA-FILTERED MILK OR MICELLAR CASEIN ISOLATE | N.V. Nutricia (NL) | 2026-03-11 | — | — | EP | claimed |
| US-20260053157-A1 | Dephosphorylation of skim milk, ultra-filtered milk or micellar casein isolate | N.V. NUTRICIA (NL) | 2026-02-26 | — | — | US | claimed |
| US-20260014403-A1 | ENVIRONMENTALLY-CLEAN WATER-BASED FIRE INHIBITING BIOCHEMICAL COMPOSITIONS, SOLUTIONS, POWDERS AND METHODS OF AND APPARATUS FOR PRODUCING FIRE PROTECTED WOOD AND ENGINEERED WOOD PRODUCTS | MIGHTY FIRE BREAKER LLC (US) | 2026-01-15 | — | — | US | claimed |
| EP-4651722-A1 | A BIO-PRESERVATION STICKER, METHODS OF PRODUCING THE SAME AND USES THEREOF | Liva Bio Protection Technologies Ltd (IL) | 2025-11-26 | — | — | EP | claimed |
| EP-4646583-A1 | POTASSIUM MALEATE BUFFER FOR FREE CHLORINE ANALYSIS | Hach Company (US) | 2025-11-12 | — | — | EP | claimed |
| US-20250268918-A1 | METHODS FOR MAKING REDUCED PARTICLE SIZE COMPOUNDS | TAP PHARMACEUTICALS, AG (CH) | 2025-08-28 | — | — | US | claimed |
| US-20250268824-A1 | METHODS FOR MAKING REDUCED PARTICLE SIZE COMPOUNDS | TAP PHARMACEUTICALS AG (CH) | 2025-08-28 | — | — | US | claimed |
| EP-4540326-A1 | STORAGE STABILIZATION AGENT FOR STABILIZING AQUEOUS COMPOSITIONS, PROCESS FOR STABILIZING AND USES THEREOF | Omya International AG (CH) | 2025-04-23 | — | — | EP | claimed |
| CN-119421931-A | Storage stabilizer for stabilizing aqueous compositions, method for stabilizing same and use thereof | 欧米亚国际集团 | 2025-02-11 | — | — | CN | claimed |
| CN-87101893-A | Ether carboxylate detergent builders and method for making thereof | — | 1987-09-16 | — | — | CN | claimed |
| EP-0232114-A2 | Ether carboxylate detergent builders and process for their preparation | THE PROCTER & GAMBLE COMPANY (US) | 1987-08-12 | — | — | EP | claimed |
| US-4668735-A | MONOSODIUM, MONOPOTASSIUM, MONOAMMONIUM MALEATE; SOLUTION POLYMERIZATION | KAO CORPORATION (JP) | 1987-05-26 | — | — | US | claimed |
| US-4663071-A | TARTRATE MONO AND DISUCCINATES | THE PROCTER & GAMBLE COMPANY (US) | 1987-05-05 | — | — | US | claimed |
| US-4610965-A | Adsorption-desorption purification of glucose isomerase | NABISCO BRANDS, INC. (US) | 1986-09-09 | — | — | US | claimed |
| EP-0185379-A2 | A process for the production of purified glucose isomerase | NABISCO BRANDS, Inc. (US) | 1986-06-25 | — | — | EP | claimed |
| US-4162188-A | IN PRESENCE OF MALEIC ACID OR ITS SODIUM OR POTASSIUM SALT, MESACONIC ACID OR ITS SODIUM SALT, OR MALEIC ANHYDRIDE | HONSHU SEISHI KABUSHIKI KAISHA (JP) | 1979-07-24 | — | — | US | claimed |
| US-4061465-A | Creasable durable press textiles from methylol reagents and half amides or half salts of dicarboxylic acids | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 1977-12-06 | — | — | US | claimed |
| US-4040970-A | WITH COPOLYMER FOR RENDERING THE TONER NEGATIVELY CHARGEABLE | CANON KABUSHIKI KAISHA (JA) | 1977-08-09 | — | — | US | claimed |
| US-3977983-A | Liquid developer for use in development of an electrostatic latent image comprising a copolymer containing an amino group converted into a quaternary ammonium salt or hydroxide | CANON KABUSHIKI KAISHA (JA) | 1976-08-31 | — | — | US | claimed |