Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27255931 | 0.84 | KDM4E (0.72) | MEN1KMT2AKDM4EMAPTRAB9A | |
| 2-(2'-Methoxyphenyl)-1H-Indole SCHEMBL5634916 | 0.83 | KDM4E (1.00) | MEN1KMT2AKDM4EMAPTRAB9A | |
| 2-(2'-Methoxyphenyl)-1H-Indole SCHEMBL31053096 | 0.83 | KDM4E (1.00) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL14764957 | 0.82 | RAB9A (0.70) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL1459848 | 0.80 | CYP19A1 (0.61) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL15057576 | 0.79 | KDM4E (0.65) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL1459791 | 0.77 | CYP19A1 (0.61) | MEN1KMT2AKDM4EMAPTRAB9A | |
| SCHEMBL11474936 | 0.77 | CYP19A1 (0.61) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL1459055 | 0.77 | CYP19A1 (0.61) | MEN1KMT2AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL28167677 | 0.77 | CYP19A1 (0.61) | MEN1KMT2AKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006113458-A1 | HETEROCYCLIC INHIBITORS OF PROTEIN ARGININE METHYL TRANSFERASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-26 | — | — | WO | disclosed |
| US-20060235037-A1 | Heterocyclic inhibitors of protein arginine methyl transferases | BRISTOL-MYERS SQUIBB COMPANY | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235037-A1 | Heterocyclic inhibitors of protein arginine methyl transferases | PRMT1, PRMT3, PRMT8 | MEN1 2684/4885KMT2A 455/4885KDM4E 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.