Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079169 | 0.99 | KDM4E (0.44) | KDM4EPTGER4RXRARXRBRXRG | |
| Potassium Ion SCHEMBL5819229 | 0.98 | KDM4E (0.43) | KDM4EPTGER4RXRARXRBRXRG | |
| SCHEMBL5788805 | 0.90 | KDM2B (0.40) | KDM4EPTGER4RXRARXRBRXRG | |
| SCHEMBL5788801 | 0.90 | PTGER4 (0.39) | KDM4EPTGER4RXRARXRBRXRG | |
| SCHEMBL4088986 | 0.88 | RXRA (0.40) | KDM4EPTGER4RXRARXRBRXRG | |
| SCHEMBL5786180 | 0.85 | RXRA (0.38) | KDM4EPTGER4RXRARXRBRXRG | |
| SCHEMBL5788803 | 0.84 | CD274 (0.49) | KDM4EPTGER4ALDH1A1MAPTPOLB | |
| SCHEMBL4094652 | 0.84 | RAB9A (0.37) | KDM4ERXRARXRBRXRGSRC | |
| SCHEMBL4085469 | 0.84 | CHRNB2 (0.43) | RXRARXRBRXRG | |
| SCHEMBL4085472 | 0.84 | CHRNB2 (0.43) | RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692128-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051942-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-06-09 | — | — | WO | disclosed |