Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220496 | 1.00 | DRD2 (0.38) | DRD2CACNA1BPPARGPPARAALDH1A1 | |
| SCHEMBL5220500 | 1.00 | DRD2 (0.38) | DRD2CACNA1BPPARGPPARAALDH1A1 | |
| SCHEMBL5223502 | 0.83 | DRD2 (0.34) | DRD2CACNA1BPPARGPPARACCR5 | |
| SCHEMBL5223506 | 0.83 | DRD2 (0.34) | DRD2CACNA1BPPARGPPARACCR5 | |
| SCHEMBL5219319 | 0.81 | DRD2 (0.40) | DRD2CACNA1BPPARGPPARAALDH1A1 | |
| SCHEMBL5336521 | 0.81 | DRD2 (0.40) | DRD2CACNA1BPPARGPPARAALDH1A1 | |
| SCHEMBL5220710 | 0.78 | FPR1 (0.41) | ALDH1A1GAA | |
| SCHEMBL5220717 | 0.78 | FPR1 (0.41) | ALDH1A1GAA | |
| SCHEMBL5223510 | 0.78 | CCR5 (0.33) | DRD2CACNA1BPPARGPPARARORC | |
| SCHEMBL5760995 | 0.77 | DRD2 (0.42) | DRD2ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663966-A1 | 1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | Novartis AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026113-A1 | 1, 3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | NOVARTIS AG (CH) | 2005-03-24 | — | — | WO | disclosed |