Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819466 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL14567505 | 0.92 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL6810293 | 0.85 | APLNR (0.33) | ALDH1A1CYP3A4IDO1AGXTCYP2C19 | |
| SCHEMBL5816125 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL5816133 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL5819052 | 0.80 | IDO1 (0.33) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL5819050 | 0.80 | IDO1 (0.33) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL5819046 | 0.80 | IDO1 (0.33) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL14567513 | 0.80 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 | |
| SCHEMBL14567504 | 0.80 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1CYP3A4TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7148218-B2 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors | NOVARTIS AG (CH) | 2006-12-12 | — | — | US | disclosed |
| EP-1312608-B1 | Discodermolide analogues and their pharmaceutical use | NOVARTIS AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| US-20050080080-A1 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors | KINDER FREDERICK R (US) | 2005-04-14 | — | — | US | disclosed |
| US-6833367-B2 | A polyhydroxy-polymethyl-8-tridecenoic acid 8-lactone compounds, as antitumor agents, anticarcinogenic agents | NOVARTIS AC (CH) | 2004-12-21 | — | — | US | disclosed |
| US-20030153601-A1 | Certain substituted polyketides, pharmac eutical compositions containing them and their use in treating tumors | NOVARTIS AG (CH) | 2003-08-14 | — | — | US | disclosed |
| EP-1312608-A2 | Discodermolide analogues and their pharmaceutical use | Novartis AG (CH) | 2003-05-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153601-A1 | Certain substituted polyketides, pharmac eutical compositions containing them and their use in treating tumors | PBK, BCKDK, ETV6 | SMN1; SMN2 3663/4885ALDH1A1 336/4885CYP3A4 831/4885 |
| US-20050080080-A1 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors | PBK, HCCS, BCKDK | SMN1; SMN2 4273/4885ALDH1A1 912/4885CYP3A4 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.