Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804817 | 0.91 | NTRK1 (0.59) | NTRK1MAPTKDM4EGAAMEN1 | |
| SCHEMBL5820018 | 0.89 | NTRK1 (0.54) | NTRK1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL5813421 | 0.88 | NTRK1 (0.55) | NTRK1MAPTKDM4EGAAKMT2A | |
| SCHEMBL5804854 | 0.81 | NTRK1 (0.54) | NTRK1MAPTKDM4EGAAMEN1 | |
| SCHEMBL5814366 | 0.77 | NTRK1 (0.57) | NTRK1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL5819741 | 0.77 | NTRK1 (0.57) | NTRK1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL5801916 | 0.73 | NTRK1 (0.58) | NTRK1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL5813435 | 0.73 | NTRK1 (0.58) | NTRK1MAPTKDM4EGAAMEN1 | |
| SCHEMBL5804272 | 0.73 | NTRK1 (0.62) | NTRK1MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL16595137 | 0.71 | NTRK1 (1.00) | NTRK1MAPTKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | claimed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |