Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804817 | 0.84 | NTRK1 (0.59) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5814366 | 0.83 | NTRK1 (0.57) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5813421 | 0.79 | NTRK1 (0.55) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5820018 | 0.79 | NTRK1 (0.54) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5819700 | 0.77 | NTRK1 (0.51) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL16595137 | 0.75 | NTRK1 (1.00) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5815917 | 0.74 | NTRK1 (0.65) | NTRK1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL8259077 | 0.73 | NTRK1 (0.71) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5804854 | 0.73 | NTRK1 (0.54) | NTRK1ALDH1A1KDM4EPOLBGAA | |
| SCHEMBL5804272 | 0.73 | NTRK1 (0.62) | NTRK1ALDH1A1KDM4EPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | claimed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |