Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 10/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819961 | 1.00 | ATM (0.43) | ATMRENCYP3A4L3MBTL1SLC6A4 | |
| SCHEMBL5668307 | 0.89 | REN (0.41) | ATMRENCYP3A4 | |
| SCHEMBL5668304 | 0.89 | REN (0.41) | ATMRENCYP3A4 | |
| SCHEMBL1752405 | 0.89 | REN (0.41) | ATMRENCYP3A4 | |
| SCHEMBL2473476 | 0.81 | REN (0.44) | RENCYP3A4KCNH2 | |
| SCHEMBL12750478 | 0.80 | REN (0.39) | ATMRENCYP3A4L3MBTL1 | |
| SCHEMBL4785962 | 0.80 | REN (0.63) | RENCYP3A4 | |
| SCHEMBL4785977 | 0.80 | REN (0.63) | RENCYP3A4 | |
| SCHEMBL4785966 | 0.80 | REN (0.63) | RENCYP3A4 | |
| SCHEMBL1751812 | 0.79 | NPBWR1 (0.39) | L3MBTL1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680427-A1 | DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040173-A1 | DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-05-06 | — | — | WO | disclosed |