Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16919139 | 0.73 | ALDH1A1 (0.49) | KDM4EHSD17B10HPGDPTPRBALDH1A1 | |
| SCHEMBL1345232 | 0.73 | GAA (0.42) | KDM4EHSD17B10HPGDPTPRBALDH1A1 | |
| SCHEMBL24455228 | 0.72 | NOS2 (0.40) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL28781635 | 0.71 | HPGD (0.37) | HSD17B10HPGDPTPRBALDH1A1SMN1; SMN2 | |
| SCHEMBL19475136 | 0.71 | GAA (0.45) | KDM4EHSD17B10HPGDPTPRBALDH1A1 | |
| SCHEMBL6952630 | 0.70 | NR3C2 (0.52) | — | |
| SCHEMBL27955096 | 0.70 | ATR (0.53) | KDM4EEGFR | |
| SCHEMBL23373281 | 0.70 | NR3C2 (0.42) | KDM4EHSD17B10ALDH1A1TSHRLMNA | |
| SCHEMBL8825478 | 0.69 | ALDH1A1 (0.53) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL31048845 | 0.69 | LMNA (0.45) | KDM4EALDH1A1SMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670798-A1 | AMINOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS | Altana Pharma AG (DE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005061496-A1 | AMINOPYRIDINE-DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS | ALTANA PHARMA AG (DE) | 2005-07-07 | — | — | WO | disclosed |