Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249978 | 0.78 | LMNA (0.40) | ALDH1A1LMNATSHRGAAKDM4E | |
| SCHEMBL29760183 | 0.74 | TSHR (0.48) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL7006546 | 0.74 | TSHR (0.48) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL31597058 | 0.73 | ALDH1A1 (0.47) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL25337052 | 0.73 | ALDH1A1 (0.47) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL8564571 | 0.72 | MAPT (0.43) | MAPTALDH1A1LMNAPTGESRAB9A | |
| SCHEMBL28046347 | 0.72 | HTT (0.42) | MAPTALDH1A1LMNARAB9AKMT2A | |
| SCHEMBL18585904 | 0.71 | TSHR (0.55) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL19204031 | 0.70 | ALDH1A1 (0.41) | MAPTALDH1A1LMNATSHRCYP3A4 | |
| Ammonia Solution, Strong SCHEMBL25335787 | 0.70 | ALDH1A1 (0.44) | MAPTALDH1A1LMNATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732562-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006083491-A2 | SUBSTITUTED PYRIDINYL AND PYRIMIDINYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |