Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 10/20 | 0.47 |
| ▸ | MMP2 | P08253 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 5/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805117 | 0.81 | ALDH1A1 (0.41) | ALDH1A1PTGESALOX5KMT2AATM | |
| SCHEMBL5807701 | 0.81 | MEN1 (0.41) | ALDH1A1KMT2AATML3MBTL1 | |
| SCHEMBL5808774 | 0.80 | ALDH1A1 (0.59) | ALDH1A1PTGESALOX5KMT2A | |
| SCHEMBL5809123 | 0.78 | NTRK1 (0.38) | ALDH1A1KMT2AATML3MBTL1 | |
| SCHEMBL8264053 | 0.78 | ALDH1A1 (0.38) | ALDH1A1PTGESALOX5KMT2AATM | |
| SCHEMBL5806376 | 0.78 | NTRK1 (0.37) | ALDH1A1KMT2AATML3MBTL1 | |
| SCHEMBL5804900 | 0.77 | MAPK13 (0.47) | ALDH1A1PTGESALOX5KMT2AL3MBTL1 | |
| SCHEMBL5806852 | 0.77 | ALDH1A1 (0.50) | ALDH1A1PTGESALOX5ATML3MBTL1 | |
| SCHEMBL5805188 | 0.76 | ALDH1A1 (0.46) | ALDH1A1PTGESALOX5ATML3MBTL1 | |
| SCHEMBL5809144 | 0.75 | MAPT (0.46) | ALDH1A1ATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |