Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805117 | 0.85 | ALDH1A1 (0.41) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL5820740 | 0.83 | ALDH1A1 (0.43) | MAPTEGFRERBB2ALDH1A1HTT | |
| SCHEMBL5807701 | 0.81 | MEN1 (0.41) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL5809123 | 0.78 | NTRK1 (0.38) | ALDH1A1HTTLMNASMN1; SMN2NTRK1 | |
| SCHEMBL5815233 | 0.78 | PTGES (0.35) | EGFRERBB2 | |
| SCHEMBL5806376 | 0.78 | NTRK1 (0.37) | ALDH1A1HTTLMNASMN1; SMN2NTRK1 | |
| SCHEMBL5804900 | 0.77 | MAPK13 (0.47) | MAPTEGFRERBB2ALDH1A1LMNA | |
| SCHEMBL5806852 | 0.77 | ALDH1A1 (0.50) | EGFRERBB2ALDH1A1HTTNTRK1 | |
| SCHEMBL8262196 | 0.77 | GUSB (0.44) | ALDH1A1HTTLMNASMN1; SMN2TP53 | |
| SCHEMBL5804793 | 0.76 | AKR1C3 (0.40) | EGFRERBB2ALDH1A1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |