Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262663 | 0.95 | NTRK1 (0.35) | NTRK1ALDH1A1HTTL3MBTL1ATM | |
| SCHEMBL5821042 | 0.94 | MAPK13 (0.43) | NTRK1ALDH1A1L3MBTL1MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL5808028 | 0.94 | NTRK1 (0.35) | NTRK1ALDH1A1HTTL3MBTL1ATM | |
| SCHEMBL5806862 | 0.93 | MAPT (0.39) | NTRK1ALDH1A1HTTL3MBTL1MAPK13 | |
| SCHEMBL5804805 | 0.92 | MAPT (0.40) | NTRK1ALDH1A1HTTL3MBTL1MAPK13 | |
| SCHEMBL5808879 | 0.92 | KMT2A (0.37) | ALDH1A1L3MBTL1ATMGAATSHR | |
| SCHEMBL8262196 | 0.88 | GUSB (0.44) | NTRK1ALDH1A1HTTL3MBTL1ATM | |
| SCHEMBL5804860 | 0.88 | ALDH1A1 (0.42) | NTRK1ALDH1A1HTTL3MBTL1ATM | |
| SCHEMBL5808980 | 0.88 | LMNA (0.43) | NTRK1ALDH1A1HTTL3MBTL1ATM | |
| SCHEMBL5806376 | 0.88 | NTRK1 (0.37) | NTRK1ALDH1A1HTTL3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |