Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581678 | 0.87 | PKM (0.36) | POLBLTA4HSMN1; SMN2PKMNPSR1 | |
| SCHEMBL581350 | 0.87 | PKM (0.36) | POLBLTA4HSMN1; SMN2PKMNPSR1 | |
| SCHEMBL581349 | 0.87 | PKM (0.36) | POLBLTA4HSMN1; SMN2PKMNPSR1 | |
| SCHEMBL582089 | 0.83 | GAA (0.35) | LTA4HKDM4ERAB9ACHRM1MEN1 | |
| SCHEMBL581942 | 0.77 | KMT2A (0.37) | LTA4HSMN1; SMN2PKMNPSR1KDM4E | |
| SCHEMBL582364 | 0.73 | HTR2A (0.41) | CHRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL582351 | 0.73 | POLB (0.48) | POLBLTA4HSMN1; SMN2MEN1KMT2A | |
| SCHEMBL582112 | 0.72 | ALDH1A1 (0.39) | CHRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL581342 | 0.72 | NPSR1 (0.43) | LTA4HSMN1; SMN2PKMNPSR1NPC1 | |
| SCHEMBL3072810 | 0.72 | NPSR1 (0.43) | LTA4HSMN1; SMN2PKMNPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |