Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581334 | 0.87 | CACNA1G (0.38) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL3085356 | 0.87 | CACNA1G (0.38) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL581333 | 0.87 | CACNA1G (0.38) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL586938 | 0.84 | FFAR4 (0.37) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL586937 | 0.84 | FFAR4 (0.37) | HTR2AHTR2CHTR7HTR6GRM2 | |
| SCHEMBL582160 | 0.81 | KMT2A (0.41) | ALDH1A1OPRM1CHRM1MEN1KMT2A | |
| SCHEMBL582882 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3075222 | 0.78 | PPARG (0.40) | ALDH1A1RECQLOPRM1CHRM1MEN1 | |
| SCHEMBL582086 | 0.78 | PPARG (0.40) | ALDH1A1RECQLOPRM1CHRM1MEN1 | |
| SCHEMBL3075705 | 0.78 | PPARG (0.40) | ALDH1A1RECQLOPRM1CHRM1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |