Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.56 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31357524 | 1.00 | MAP2K4 (0.60) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL17583974 | 0.86 | MAP2K4 (0.51) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL10091947 | 0.83 | ATM (0.60) | MAPK1KDM4EALDH1A1GAAPOLB | |
| SCHEMBL27690143 | 0.79 | MAP2K4 (0.51) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL15567154 | 0.78 | MAP2K4 (0.54) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL9876317 | 0.76 | IDO1 (0.58) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL13373573 | 0.76 | DHODH (0.61) | MAP2K4MAPK1MAPKAPK3MAPK6ITK | |
| SCHEMBL3732433 | 0.75 | MAP2K4 (1.00) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL9763795 | 0.75 | AURKA (0.50) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E | |
| SCHEMBL1672674 | 0.74 | IDO1 (0.78) | MAP2K4MAPK1MAPKAPK3MAPK6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014026327-A1 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-02-20 | — | — | WO | claimed |
| WO-2021178780-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | ESCAPE Bio, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |
| WO-2014026327-A1 | 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORGAMMAT INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2014-02-20 | — | — | WO | disclosed |
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |
| EP-0014951-A2 | Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1980-09-03 | — | — | EP | disclosed |