Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815028 | 0.91 | RAB9A (0.46) | AURKAAURKBRIPK1CYP1A2NAMPT | |
| SCHEMBL5820442 | 0.90 | HRH3 (0.43) | AURKAAURKBRIPK1CYP1A2NAMPT | |
| SCHEMBL5820856 | 0.90 | AURKA (0.41) | AURKAAURKBRIPK1CYP1A2NAMPT | |
| SCHEMBL5820310 | 0.89 | HRH3 (0.45) | AURKAAURKBRIPK1CYP1A2NAMPT | |
| SCHEMBL5820251 | 0.89 | CYP1A2 (0.45) | AURKAAURKBCYP1A2NAMPTZAP70 | |
| SCHEMBL5821064 | 0.89 | SMN1; SMN2 (0.44) | AURKAAURKBCYP1A2NAMPTZAP70 | |
| SCHEMBL5820813 | 0.89 | NAMPT (0.47) | AURKAAURKBCYP1A2NAMPTZAP70 | |
| SCHEMBL5820606 | 0.88 | KDM4E (0.44) | AURKAAURKBRIPK1CYP1A2NAMPT | |
| SCHEMBL5823039 | 0.88 | AURKA (0.50) | AURKAAURKBCYP1A2NAMPTZAP70 | |
| SCHEMBL5823980 | 0.88 | ZAP70 (0.49) | AURKAAURKBCYP1A2NAMPTZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137706-A1 | 6-(4-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES, METHOD FOR PREPARING THEREOF AND ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | B & C BIOPHARM. CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |