Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822635 | 0.88 | CMKLR1 (0.37) | CPT1ADGAT2RXRARXRBRXRG | |
| SCHEMBL5820265 | 0.87 | DGAT2 (0.37) | CPT2CPT1ADGAT2RXRARXRB | |
| SCHEMBL5823147 | 0.87 | MAP3K5 (0.34) | DGAT2RXRARXRBRXRGMAPT | |
| SCHEMBL5373140 | 0.85 | CPT2 (0.35) | CPT2CPT1ADGAT2PDE4DPDE7A | |
| SCHEMBL2967295 | 0.82 | PDE4D (0.41) | CPT2CPT1ADGAT2PDE4DPDE7A | |
| SCHEMBL5823947 | 0.82 | DGAT2 (0.36) | DGAT2RXRARXRBRXRGCMKLR1 | |
| SCHEMBL5377997 | 0.79 | MAP2K4 (0.41) | CPT2CPT1ADGAT2PDE4DPDE7A | |
| SCHEMBL5378434 | 0.78 | CREBBP (0.41) | CPT2CPT1ADGAT2PDE4DPDE7A | |
| SCHEMBL5379195 | 0.78 | PPARG (0.37) | DGAT2MEN1KMT2A | |
| SCHEMBL5377249 | 0.78 | PPARG (0.37) | DGAT2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |