Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 12/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.34 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822635 | 0.83 | CMKLR1 (0.37) | DGAT2CAMKK2CAMKK1CMKLR1RXRA | |
| SCHEMBL5823945 | 0.82 | CPT2 (0.35) | DGAT2CMKLR1PTGER4RXRARXRB | |
| SCHEMBL5820265 | 0.79 | DGAT2 (0.37) | DGAT2CMKLR1PTGER4RXRARXRB | |
| SCHEMBL5823147 | 0.79 | MAP3K5 (0.34) | DGAT2RXRARXRBRXRGATR | |
| SCHEMBL5377693 | 0.79 | DGAT2 (0.37) | DGAT2PPARGCAMKK2CAMKK1PTGER4 | |
| SCHEMBL7532527 | 0.75 | DRD1 (0.35) | DGAT2PPARGPTGER4RXRARXRB | |
| SCHEMBL5802425 | 0.71 | RXRA (0.35) | DGAT2PTGER4RXRARXRBRXRG | |
| SCHEMBL5374224 | 0.70 | DGAT2 (0.44) | DGAT2RXRARXRBRXRGATR | |
| SCHEMBL5379195 | 0.69 | PPARG (0.37) | DGAT2PPARG | |
| SCHEMBL5377249 | 0.69 | PPARG (0.37) | DGAT2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618093-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004094388-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-11-04 | — | — | WO | disclosed |