Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794763 | 0.82 | PTGDR2 (0.53) | PTGDR2DAOFFAR1ALDH1A1LMNA | |
| SCHEMBL6112072 | 0.68 | MEN1 (0.45) | PTGDR2ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL23482876 | 0.68 | TSHR (0.47) | PTGDR2DAOALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5761789 | 0.67 | NPC1 (0.54) | DAOLMNAKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL20759378 | 0.66 | DAO (0.51) | PTGDR2DAOALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18776164 | 0.65 | PTGDR2 (0.51) | PTGDR2DAOFFAR1ALDH1A1LMNA | |
| SCHEMBL23623388 | 0.65 | TSHR (0.49) | PTGDR2DAOALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10600460 | 0.65 | TSHR (0.48) | PTGDR2DAOALDH1A1LMNAHPGD | |
| Bicarbonate SCHEMBL11298239 | 0.63 | KDM4E (0.60) | ALDH1A1LMNAMAPTHPGDKMT2A | |
| SCHEMBL7346371 | 0.63 | L3MBTL1 (0.62) | FFAR1ALDH1A1LMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644353-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003118-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | WO | disclosed |