Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465585 | 0.80 | ALDH1A1 (0.46) | KDM4ESMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL29561158 | 0.80 | ALDH1A1 (0.46) | KDM4ESMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL4477389 | 0.75 | HTR4 (0.41) | SSTR4SMN1; SMN2POLBALDH1A1IMPDH2 | |
| SCHEMBL28277150 | 0.73 | ALDH1A1 (0.40) | KDM4ESMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL12535857 | 0.72 | KDM4E (0.50) | SSTR4KDM4ESMN1; SMN2HTR3ESLC22A2 | |
| SCHEMBL2738313 | 0.68 | KDM4E (0.49) | SSTR4KDM4ESMN1; SMN2NPSR1HTR3E | |
| SCHEMBL12535855 | 0.68 | KDM4E (0.43) | SSTR4KDM4ESMN1; SMN2HTR3ESLC22A2 | |
| SCHEMBL24783439 | 0.68 | SMN1; SMN2 (0.55) | SSTR4KDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL22440097 | 0.67 | KDM4E (0.42) | SSTR4KDM4ESMN1; SMN2MAPTPOLB | |
| SCHEMBL16092003 | 0.67 | KDM4E (0.41) | KDM4EMAPTNPSR1ALDH1A1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706384-A1 | THERAPEUTIC AGENTS I | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066132-A1 | THERAPEUTIC AGENTS I | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |