Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218655 | 0.78 | NLRP3 (0.35) | KMT2AALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL29561158 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19IMPDH2 | |
| SCHEMBL465585 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19IMPDH2 | |
| SCHEMBL30014534 | 0.77 | KMT2A (0.44) | HTR4KMT2AALDH1A1MPOSMN1; SMN2 | |
| SCHEMBL13322634 | 0.77 | KMT2A (0.44) | HTR4KMT2AALDH1A1MPOSMN1; SMN2 | |
| SCHEMBL5824142 | 0.75 | SSTR4 (0.41) | KMT2AALDH1A1SMN1; SMN2CYP1A2IMPDH2 | |
| SCHEMBL6112212 | 0.74 | ESR1 (0.56) | ALDH1A1MPOSMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL13174590 | 0.74 | SMN1; SMN2 (0.49) | HTR4KMT2AALDH1A1MPOSMN1; SMN2 | |
| SCHEMBL31495822 | 0.74 | SMN1; SMN2 (0.49) | HTR4KMT2AALDH1A1MPOSMN1; SMN2 | |
| SCHEMBL6652043 | 0.73 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180333-B1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-ISOPROPYL-3-{5- [1-(3-METHOXYPROPYL) PIPERIDIN-4-YL]-[1,3,4]OXADIAZOL-2-YL}-1H-INDAZOLE OXALATE | SUVEN LIFE SCIENCES LTD (IN) | 2020-07-08 | — | — | EP | claimed |
| CN-110669107-A | Antibacterial peptide and preparation method thereof | 上海医药工业研究院 | 2020-01-10 | — | — | CN | claimed |
| CN-106604921-B | The method that 1- isopropyl -3- { 5- [1- (3- methoxy-propyl) piperidin-4-yl]-[1,3,4] oxadiazoles -2- base } -1H- indazole oxalates is mass produced | 苏文生命科学有限公司 | 2019-04-02 | — | — | CN | claimed |
| CN-106604921-A | Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate | 苏文生命科学有限公司 | 2017-04-26 | — | — | CN | claimed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | claimed |
| CN-110669107-A | Antibacterial peptide and preparation method thereof | 上海医药工业研究院 | 2020-01-10 | — | — | CN | disclosed |
| CN-106604921-B | The method that 1- isopropyl -3- { 5- [1- (3- methoxy-propyl) piperidin-4-yl]-[1,3,4] oxadiazoles -2- base } -1H- indazole oxalates is mass produced | 苏文生命科学有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-106604921-A | Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate | 苏文生命科学有限公司 | 2017-04-26 | — | — | CN | disclosed |
| US-7598286-B2 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2007010390-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2007-01-25 | — | — | WO | disclosed |
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | WYETH (US) | 2006-05-18 | — | — | US | disclosed |
| WO-2006050006-A2 | ((1H-INDAZOL-3-YL)METHYL) PHENOLS AND (HYDROXYPHENYL)(1H-INDAZOL-3-YL) METHANONES AS LIGANDS OF THE ESTROGEN RECEPTOR | WYETH (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106084-A1 | [(1H-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1H-indazol-3-yl)methanones | PTGS1, NOS3, PTGIS | HTR4 303/4885KMT2A 3116/4885ALDH1A1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.