Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241368 | 0.78 | AKR1B1 (0.55) | — | |
| SCHEMBL3573836 | 0.77 | ALDH1A1 (0.42) | TDP1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL5824475 | 0.77 | CTBP2 (0.50) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL5824570 | 0.77 | CTBP2 (0.50) | MEN1KMT2APKMMAPTALDH1A1 | |
| Isothiocyanate SCHEMBL27938294 | 0.75 | TDP1 (0.80) | TDP1L3MBTL1CYP1A2MEN1KMT2A | |
| SCHEMBL5432554 | 0.75 | TDP1 (0.59) | TDP1L3MBTL1CYP1A2MEN1KMT2A | |
| SCHEMBL7565966 | 0.75 | TDP1 (0.74) | TDP1L3MBTL1CYP1A2SIRT5MEN1 | |
| SCHEMBL30774302 | 0.75 | TDP1 (0.74) | TDP1L3MBTL1CYP1A2SIRT5MEN1 | |
| SCHEMBL3620817 | 0.74 | GABRA1 (0.35) | — | |
| SCHEMBL590845 | 0.74 | TDP1 (0.67) | TDP1L3MBTL1CYP1A2SIRT5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105646348-A | Naphthalene dicarboamide naphthalene acyl thiourea compound and application thereof | 青岛科技大学 | 2016-06-08 | — | — | CN | claimed |
| CN-106232102-A | Topical composition | 荷兰联合利华有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-105646348-A | Naphthalene dicarboamide naphthalene acyl thiourea compound and application thereof | 青岛科技大学 | 2016-06-08 | — | — | CN | disclosed |
| CN-103845345-A | Hepatitis treatment medicament | INST PHARM & TOXICOLOGY AMMS | 2014-06-11 | — | — | CN | disclosed |
| CN-102961688-B | Traditional Chinese medicine decoction capable of reducing alpha fetoprotein and preventing and treating liver cancer | JIAO KEDE | 2014-03-26 | — | — | CN | disclosed |
| CN-103508981-A | New piperazine derivative and medical applications | BEIJING MEIBEITA PHARMACEUTICAL RES CO LTD | 2014-01-15 | — | — | CN | disclosed |
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | TDP1 1586/4885L3MBTL1 1545/4885CYP1A2 1807/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | TDP1 2348/4885L3MBTL1 1895/4885CYP1A2 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.