Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PLA2G4B | P0C869 | 6/20 | 0.60 |
| ▸ | RARB | P10826 | 3/20 | 0.57 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | THRA | P10827 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5824643 | 0.99 | TP53 (0.59) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL5824697 | 0.96 | TP53 (0.54) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL5824467 | 0.83 | PARP10 (0.54) | PLA2G4BNPC1LMNAMAPTALOX15 | |
| SCHEMBL21138607 | 0.82 | TP53 (0.69) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL5824641 | 0.79 | THRA (0.55) | RARBMAPTTHRATHRB | |
| SCHEMBL18302060 | 0.78 | TP53 (0.77) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL533825 | 0.78 | TP53 (0.77) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL1623628 | 0.78 | TP53 (0.77) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL2847927 | 0.78 | TP53 (0.77) | TP53TSHRPLA2G4BRARBPLA2G4A | |
| SCHEMBL15558380 | 0.78 | TP53 (0.77) | TP53TSHRPLA2G4BRARBPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135466-B2 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-09-21 | — | — | US | disclosed |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | KIRIN HOLDINGS KABUSHIKI KAISHA (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1243582-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211717-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | TP53 2642/4885TSHR 293/4885PLA2G4B 3938/4885 |
| US-20040132727-A1 | Quinoline and quinazoline derivatives and drugs containing the same | PDGFRA, PDGFRB, PDGFA | TP53 2896/4885TSHR 394/4885PLA2G4B 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.