Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827662 | 0.88 | PRKCA (0.49) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828608 | 0.87 | PRKCA (0.49) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828121 | 0.82 | LMNA (0.46) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL6729840 | 0.81 | PRKCA (0.55) | PRKCAPRKCQTOP1CHEK1ROCK2 | |
| SCHEMBL5827642 | 0.81 | PRKCA (0.43) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828918 | 0.81 | PRKCA (0.41) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828557 | 0.80 | PRKCA (0.44) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828683 | 0.79 | PRKCA (0.84) | PRKCAPRKCQTOP1 | |
| SCHEMBL5828079 | 0.78 | GALR3 (0.40) | PRKCALMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL5828937 | 0.78 | GALR3 (0.40) | PRKCALMNATHRBSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |