Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022996 | 0.85 | KMT2A (0.51) | SRCBRAFKDRKMT2AKDM4E | |
| SCHEMBL6268028 | 0.77 | CYP2C9 (0.54) | KMT2AKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL28191530 | 0.76 | SMN1; SMN2 (0.50) | BRAFKMT2AKDM4ELMNAMAPT | |
| SCHEMBL398111 | 0.75 | KMT2A (0.59) | KMT2AKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL11084830 | 0.73 | MAPT (0.46) | SRCBRAFKDRKMT2AKDM4E | |
| SCHEMBL11403233 | 0.73 | KMT2A (0.52) | SRCBRAFKDRKMT2AKDM4E | |
| SCHEMBL16578381 | 0.72 | KMT2A (0.60) | KMT2AKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL2560074 | 0.72 | KMT2A (0.56) | KMT2AKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL15072191 | 0.72 | ALDH1A1 (0.72) | SRCBRAFKDRKMT2AKDM4E | |
| SCHEMBL30701191 | 0.72 | NPC1 (0.73) | KMT2AKDM4ELMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071198-B1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |