Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 15/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879330 | 0.91 | OPRD1 (0.58) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5629711 | 0.88 | OPRD1 (0.60) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829898 | 0.87 | OPRD1 (0.51) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5830266 | 0.86 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829897 | 0.85 | OPRD1 (0.46) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5829612 | 0.85 | OPRD1 (0.48) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5828654 | 0.85 | OPRD1 (0.51) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829817 | 0.83 | OPRD1 (0.46) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5829932 | 0.83 | OPRD1 (0.48) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829642 | 0.83 | OPRM1 (0.47) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | claimed |