Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 8/20 | 0.60 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.55 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.55 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319628 | 0.82 | ASH1L (0.67) | HPGDSPIK3CDPIK3CBPIK3CGASH1L | |
| SCHEMBL19608224 | 0.82 | ASH1L (0.71) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL21004067 | 0.82 | ASH1L (0.56) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL20552280 | 0.82 | HPGDS (0.75) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL2947880 | 0.81 | PIK3CD (0.57) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL11992420 | 0.78 | PIP4K2A (0.58) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL31527594 | 0.78 | KEAP1 (0.49) | HPGDSMKNK1MKNK2 | |
| SCHEMBL29954839 | 0.78 | HPGDS (0.54) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL20551973 | 0.77 | HPGDS (0.68) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD | |
| SCHEMBL5831050 | 0.76 | PIK3CD (0.68) | HPGDSPIP4K2APIP4K2BPIP4K2CPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053086-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2004-05-20 | — | — | US | disclosed |
| US-6635640-B2 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2003-10-21 | — | — | US | disclosed |
| EP-1296975-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | SUGEN, INC. | 2002-12-12 | — | — | US | disclosed |
| WO-2002002551-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187978-A1 | 4-Heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | HPGDS 797/4885PIP4K2A 266/4885PIP4K2B 270/4885 |
| US-20040097497-A1 | 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors | CDK2, CDK20, CDK3 | HPGDS 797/4885PIP4K2A 266/4885PIP4K2B 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.