Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.54 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.54 |
| ▸ | TK1 | P04183 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5832481 | 1.00 | TYMS (0.60) | TYMSPOLBP2RY2P2RY4TK1 | |
| SCHEMBL3063249 | 0.91 | TYMS (0.68) | TYMSPOLBTK1 | |
| SCHEMBL8428624 | 0.91 | TYMS (0.68) | TYMSPOLBTK1 | |
| Ammonia Solution, Strong SCHEMBL8170309 | 0.90 | TYMS (0.67) | TYMSPOLBTK1 | |
| SCHEMBL8424931 | 0.87 | POLB (0.67) | TYMSPOLBTK1 | |
| SCHEMBL2057388 | 0.86 | TYMS (0.64) | TYMSPOLBP2RY2TK1 | |
| SCHEMBL8453167 | 0.86 | POLB (0.60) | TYMSPOLBTK1 | |
| SCHEMBL20582548 | 0.83 | TYMS (0.63) | TYMSPOLBP2RY2TK1 | |
| Thymidine Monophosphate SCHEMBL20797966 | 0.82 | TYMS (0.75) | TYMSPOLBTK1 | |
| SCHEMBL2181728 | 0.82 | POLB (0.78) | TYMSPOLBTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087736-B1 | Tyrosine DNA phosphodiesterases (TDP) and related polypeptides nucleic acids vectors TDP producing host cells antibodies and methods of use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-08-08 | — | — | US | disclosed |
| WO-2001025407-A2 | TYROSINE-DNA PHOSPHODIESTERASES (TDP) AND RELATED POLYPEPTIDES, NUCLEIC ACIDS, VECTORS, TDP-PRODUCING HOST CELLS, ANTIBODIES AND METHODS OF USE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-04-12 | — | — | WO | disclosed |