Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TK1 | P04183 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063249 | 1.00 | TYMS (0.68) | TYMSPOLBTK1 | |
| Ammonia Solution, Strong SCHEMBL8170309 | 0.99 | TYMS (0.67) | TYMSPOLBTK1 | |
| SCHEMBL2057388 | 0.95 | TYMS (0.64) | TYMSPOLBTK1 | |
| SCHEMBL20582548 | 0.92 | TYMS (0.63) | TYMSPOLBTK1 | |
| SCHEMBL11587776 | 0.91 | TYMS (0.65) | TYMSPOLBTK1 | |
| SCHEMBL21003255 | 0.91 | TYMS (0.65) | TYMSPOLBTK1 | |
| SCHEMBL5832481 | 0.91 | TYMS (0.60) | TYMSPOLBTK1 | |
| SCHEMBL5832477 | 0.91 | TYMS (0.60) | TYMSPOLBTK1 | |
| SCHEMBL8170305 | 0.90 | TYMS (0.63) | TYMSPOLBTK1 | |
| Doxribtimine SCHEMBL20797965 | 0.88 | TYMS (0.63) | TYMSPOLBTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260049294-A1 | ENPP1 Polypeptides and Methods of Using Same | UNIV YALE (US) | 2026-02-19 | — | — | US | disclosed |
| US-20260022356-A1 | NPP1 Fusion Proteins | INOZYME PHARMA INC (US) | 2026-01-22 | — | — | US | disclosed |
| US-20250230423-A1 | ENPP1 POLYPEPTIDES AND METHODS OF USING SAME | UNIV YALE (US) | 2025-07-17 | — | — | US | disclosed |
| US-12344868-B2 | ENPP1 polypeptides and methods of using same | YALE UNIVERSITY (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250115609-A1 | AROMATIC HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF | INNOVSTONE THERAPEUTICS LIMITED (CN) | 2025-04-10 | — | — | US | disclosed |
| EP-4450503-A1 | AROMATIC HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF | Innovstone Therapeutics Limited (CN) | 2024-10-23 | — | — | EP | disclosed |
| CN-117883449-A | ENPP1 inhibitors and their use for the treatment of cancer | 里兰斯坦福初级大学理事会 | 2024-04-16 | — | — | CN | disclosed |
| CN-111372587-B | ENPP1 inhibitors and their use for the treatment of cancer | 里兰斯坦福初级大学理事会 | 2024-01-09 | — | — | CN | disclosed |
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230129977-A1 | NPP1 FUSION PROTEINS | BIOMARIN PHARMACEUTICAL INC. | 2023-04-27 | — | — | US | disclosed |
| CN-113677350-A | ENPP1 inhibitors and methods of modulating immune responses | 里兰斯坦福初级大学理事会 | 2021-11-19 | — | — | CN | disclosed |
| EP-3844280-A1 | ENPP1 POLYPEPTIDES AND METHODS OF USING SAME | Yale University (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2021053507-A1 | 2-AMINO-S6-SUBSTITUTED THIOPURINE COMPOUNDS AS INHIBITORS OF THE ENPP1 PROTEIN | ATEN PORUS LIFESCIENCES PVT. LTD. (IN) | 2021-03-25 | — | — | WO | disclosed |
| WO-2020212995-A1 | HIGHLY SELECTIVE AND POTENT NPP1 INHIBITORS BASED ON URIDINE-5'-P,-DITHIOPHOSPHATE ANALOGUES | BAR-ILAN UNIVERSITY (IL) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020206302-A1 | ENPP1 POLYPEPTIDES AND METHODS OF USING SAME | YALE UNIVERSITY (US) | 2020-10-08 | — | — | WO | disclosed |
| CN-111372587-A | ENPP1 inhibitors and their use for treating cancer | 里兰斯坦福初级大学理事会 | 2020-07-03 | — | — | CN | disclosed |
| WO-2020047520-A1 | ENPP1 POLYPEPTIDES AND METHODS OF USING SAME | YALE UNIVERSITY (US) | 2020-03-05 | — | — | WO | disclosed |
| US-20140378408-A1 | NUCLEOSIDE 5'-PHOSPHOROTHIOATE ANALOGUES AND USES THEREOF | BAR ILAN UNIVERSITY AN ISRAELI UNIVERSITY (IL) | 2014-12-25 | — | — | US | disclosed |
| WO-2013132489-A1 | NUCLEOSIDE 5'-PHOSPHOROTHIOATE ANALOGUES AND USES THEREOF | BAR-ILAN UNIVERSITY (IL) | 2013-09-12 | — | — | WO | disclosed |
| US-5962291-A | MONOCLONAL ANTIBODY CAPABLE OF HYDROLYZING A SUBSTRATE; HAS TWO BINDING SITES: ONE FOR FREE METAL ION, ONE FOR SUBSTRATE | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 1999-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378408-A1 | NUCLEOSIDE 5'-PHOSPHOROTHIOATE ANALOGUES AND USES THEREOF | CCL2, NUDT1, CXCL12 | TYMS 100/4885POLB 693/4885TK1 88/4885 |
| US-20260049294-A1 | ENPP1 Polypeptides and Methods of Using Same | ENPP1, ENPP3, PNP | TYMS 713/4885POLB 945/4885TK1 463/4885 |
| US-20260022356-A1 | NPP1 Fusion Proteins | SPPL2B, LNPEP, CPN1 | TYMS 1737/4885POLB 2525/4885TK1 249/4885 |
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | TYMS 256/4885POLB 392/4885TK1 143/4885 |
| US-20250115609-A1 | AROMATIC HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF | ENPP1, WEE1, ENPP2 | TYMS 175/4885POLB 3807/4885TK1 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.