Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 9/20 | 0.58 |
| ▸ | FPR3 | P25089 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | SETD1B | Q9UPS6 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039 | 0.83 | FPR3 (0.54) | FPR2FPR3SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL31203335 | 0.76 | HDAC6 (0.68) | FPR2FPR3 | |
| SCHEMBL5835735 | 0.76 | SMN1; SMN2 (0.83) | SMN1; SMN2MAPK10CCNE1CDK2CDK5 | |
| SCHEMBL28830687 | 0.76 | FPR3 (0.47) | FPR2FPR3SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL28523289 | 0.75 | LMNA (0.65) | SMN1; SMN2CA1CA2 | |
| SCHEMBL27739667 | 0.75 | FPR3 (0.47) | FPR2FPR3SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL2683840 | 0.74 | FPR2 (1.00) | FPR2FPR3 | |
| SCHEMBL5835100 | 0.74 | SMN1; SMN2 (0.70) | FPR2FPR3SMN1; SMN2MAPK10CCNE1 | |
| SCHEMBL3870395 | 0.74 | FPR3 (0.48) | FPR2FPR3KDM4E | |
| SCHEMBL4167491 | 0.73 | CA1 (0.46) | FPR2FPR3KDM4EPOLBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |