Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956259 | 0.83 | CCNE1 (0.67) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2369978 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2370583 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL5836087 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL10176139 | 0.80 | ALDH1A1 (0.48) | SMN1; SMN2CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL13934304 | 0.79 | CDK2 (0.67) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2370823 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL18541910 | 0.78 | MEN1 (0.65) | SMN1; SMN2CDK2POLBNPC1RAB9A | |
| SCHEMBL18541911 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2655832 | 0.75 | L3MBTL1 (0.56) | SMN1; SMN2GLSCSNK2A2CSNK2A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026202-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-05-11 | — | — | WO | disclosed |