Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.53 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GLS | O94925 | 1/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956259 | 0.85 | CCNE1 (0.67) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2369978 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL5836087 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL5835534 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL2370823 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL13934304 | 0.81 | CDK2 (0.67) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL18541910 | 0.80 | MEN1 (0.65) | SMN1; SMN2CDK2POLBNPC1RAB9A | |
| SCHEMBL18541911 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL10009618 | 0.79 | JAK2 (0.54) | SMN1; SMN2CCNE1CDK2CCNE2POLB | |
| SCHEMBL32671861 | 0.79 | CCNE1 (0.65) | SMN1; SMN2CCNE1CDK2POLBGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130281708-A1 | Process for the Production of 2-Amino-5-Fluorothiazole | TAKEDA CALIFORNIA, INC. (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130281708-A1 | Process for the Production of 2-Amino-5-Fluorothiazole | TAKEDA CALIFORNIA, INC. (US) | 2013-10-24 | — | — | US | disclosed |
| EP-2547667-A1 | PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE | Takeda California, Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115758-A1 | PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE | TAKEDA SAN DIEGO, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011115758-A1 | PROCESS FOR THE PRODUCTION OF 2-AMINO-5-FLUOROTHIAZOLE | TAKEDA SAN DIEGO, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281708-A1 | Process for the Production of 2-Amino-5-Fluorothiazole | GFPT1, PFAS, PFKFB4 | SMN1; SMN2 3947/4885CCNE1 100/4885CDK2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.