SCHEMBL5836031

SCHEMBL5836031

CC1=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc2C1[Si](C)(C)C1C(C)=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
DRD2 P14416 1/20 0.36
POLB P06746 2/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C19 P33261 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KIF11 P52732 2/20 0.34
ENPP1 P22413 1/20 0.34
CYP11B1 P15538 3/20 0.33
CYP11B2 P19099 3/20 0.33
CHUK O15111 1/20 0.33
TXNRD1 Q16881 1/20 0.33
NOX4 Q9NPH5 1/20 0.33
GABBR2 O75899 2/20 0.33
GABBR1 Q9UBS5 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5837617 0.88 HTR1A (0.38) RAB9ASMN1; SMN2NPSR1POLBKDM4E
SCHEMBL1455223 0.88 NPC1 (0.36) RAB9ASMN1; SMN2KDM4EALDH1A1KIF11
SCHEMBL1454517 0.87 BRD4 (0.40) RAB9ASMN1; SMN2KDM4EALDH1A1CYP1A2
SCHEMBL1454590 0.84 ADORA3 (0.33) RAB9ASMN1; SMN2NPSR1POLBKDM4E
SCHEMBL5836727 0.83 JAK2 (0.34) JAK2RAB9ASMN1; SMN2NPSR1DRD2
SCHEMBL29366427 0.83 PDCD1 (0.34) RAB9ASMN1; SMN2ALDH1A1ENPP1NPC1
SCHEMBL61908 0.83 PDCD1 (0.34) RAB9ASMN1; SMN2ALDH1A1ENPP1NPC1
SCHEMBL5836984 0.82 EDNRB (0.38) CYP1A2
SCHEMBL22411215 0.82 NPC1 (0.33) RAB9ASMN1; SMN2NPC1LMNA
SCHEMBL26606293 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119661574-A Bisindene silane compound and synthetic method and application thereof 中化学科学技术研究有限公司 2025-03-21 CN disclosed
US-6984743-B1 Method for producing metallocenes BASELL POLYOLEFINE GMBH (DE) 2006-01-10 US disclosed