Betaine

Betaine

SCHEMBL5836146

C=C(C)C(=O)OCC[N+](C)(C)CCCC(=O)O.C[N+](C)(C)CC(=O)O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

BHMTBHMT2

The experimentally established mechanism targets of Betaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BBOX1 O75936 5/20 0.46
APEX1 P27695 2/20 0.42
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.42
TSHR P16473 4/20 0.40
THRB P10828 1/20 0.37
CHRM5 P08912 3/20 0.37
CHRM1 P11229 3/20 0.37
CHRM3 P20309 3/20 0.37
MAPT P10636 1/20 0.37
BLM P54132 1/20 0.37
POLB P06746 1/20 0.35
HTT P42858 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CHRM2 P08172 2/20 0.34
CHRM4 P08173 2/20 0.34
ADRA2A P08913 1/20 0.34
ADRA1A P35348 1/20 0.34
PGR P06401 1/20 0.34
HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Betaine SCHEMBL5168008 0.96 BBOX1 (0.47) BBOX1APEX1ALDH1A1LMNATSHR
SCHEMBL10041769 0.93 BBOX1 (0.53) BBOX1APEX1ALDH1A1TSHRTHRB
Betaine SCHEMBL5169156 0.92 BBOX1 (0.43) BBOX1APEX1ALDH1A1LMNATSHR
Betaine SCHEMBL5167219 0.92 APEX1 (0.44) BBOX1APEX1ALDH1A1LMNATSHR
Water SCHEMBL7094496 0.91 BBOX1 (0.51) BBOX1APEX1ALDH1A1TSHRTHRB
Betaine SCHEMBL6062726 0.87 APEX1 (0.48) APEX1ALDH1A1LMNATSHRTHRB
Bromide SCHEMBL21931269 0.86 TSHR (0.45) BBOX1APEX1ALDH1A1LMNATSHR
Bromide SCHEMBL21931193 0.86 TSHR (0.45) BBOX1APEX1ALDH1A1LMNATSHR
Betaine SCHEMBL513480 0.84 APEX1 (0.38) BBOX1APEX1ALDH1A1LMNATSHR
Hydrochloric Acid SCHEMBL32674543 0.84 THRB (0.44) APEX1ALDH1A1LMNATSHRTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7029805-B2 Imageable element with masking layer comprising betaine-containing co-polymers EASTMAN KODAK COMPANY (US) 2006-04-18 US disclosed
US-20060051700-A1 IMAGEABLE ELEMENT WITH MASKING LAYER COMPRISING BETAINE-CONTAINING CO-POLYMERS CITICORP NORTH AMERICA, INC., AS AGENT 2006-03-09 US disclosed
US-7008751-B2 Thermally switchable imageable elements containing betaine-containing co-polymers EASTMAN KODAK COMPANY (US) 2006-03-07 US disclosed
US-20060029881-A1 THERMALLY SWITCHABLE IMAGEABLE ELEMENTS CONTAINING BETAINE-CONTAINING CO-POLYMERS CITICORP NORTH AMERICA, INC., AS AGENT 2006-02-09 US disclosed