Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | YEATS4 | O95619 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.52 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.52 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.52 |
| ▸ | PLD2 | O14939 | 11/20 | 0.52 |
| ▸ | PLD1 | Q13393 | 11/20 | 0.52 |
| ▸ | HTR3A | P46098 | 2/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437610 | 0.85 | YEATS4 (0.51) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL5837066 | 0.82 | ALDH1A1 (0.62) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL14008572 | 0.79 | YEATS4 (0.66) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL5836092 | 0.79 | HPD (0.50) | ALDH1A1TSHRDRD2 | |
| SCHEMBL18477021 | 0.79 | ALDH1A1 (0.58) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL14433780 | 0.79 | EPHX2 (0.60) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL5836923 | 0.78 | GAA (0.49) | ALDH1A1TSHRKDM4EMEN1HTT | |
| SCHEMBL5837297 | 0.78 | MEN1 (0.57) | ALDH1A1LMNAHTR3AKDM4EMEN1 | |
| SCHEMBL5836240 | 0.78 | ALDH1A1 (0.58) | ALDH1A1USP2LMNAYEATS4KCNH2 | |
| SCHEMBL6054640 | 0.77 | POLB (0.63) | ALDH1A1KDM4EMEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056918-B2 | Benzimidazole anti-inflammatory compounds | PFIZER, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1370557-B1 | BENZIMIDAZOLE ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20030092749-A1 | Novel benzimidazole anti-inflammatory compounds | PFIZER INC. | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092749-A1 | Novel benzimidazole anti-inflammatory compounds | MAPK1, JAK1, CNKSR1 | ALDH1A1 1806/4885USP2 3205/4885LMNA 4261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.