Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 12/20 | 1.00 |
| ▸ | CA1 | P00915 | 4/20 | 0.88 |
| ▸ | CA2 | P00918 | 4/20 | 0.88 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.88 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.88 |
| ▸ | PARP1 | P09874 | 1/20 | 0.88 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.79 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.79 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.79 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | TNKS | O95271 | 1/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201761 | 0.94 | PARP10 (1.00) | PARP10CA1CA2PARP2PARP4 | |
| Hydrochloric Acid SCHEMBL408766 | 0.91 | PARP10 (0.95) | PARP10CA1CA2PARP2PARP4 | |
| Hydrochloric Acid SCHEMBL4376056 | 0.91 | PARP10 (0.95) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL3137816 | 0.89 | PARP10 (1.00) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL27571315 | 0.88 | PARP10 (0.88) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL7442028 | 0.88 | PARP10 (0.88) | PARP10CA1CA2PARP2PARP4 | |
| Acetic Acid SCHEMBL28396208 | 0.88 | PARP10 (0.88) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL6167256 | 0.87 | PARP10 (0.84) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL8406724 | 0.86 | PARP10 (0.84) | PARP10CA1CA2PARP2PARP4 | |
| SCHEMBL11600003 | 0.86 | PARP10 (0.84) | PARP10CA1CA2PARP2PARP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119201-B2 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER INC (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1501515-B1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PROD INC (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1501515-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040006057-A1 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | PFIZER PRODUCTS INC. | 2004-01-08 | — | — | US | disclosed |
| WO-2003090752-A1 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006057-A1 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors | MMP8, MMP9, MMP1 | PARP10 1850/4885CA1 1659/4885CA2 848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.