Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292854 | 0.84 | ADORA2A (0.63) | SMN1; SMN2NPC1RAB9AALOX15 | |
| SCHEMBL5837409 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK10ALDH1A1NPC1RAB9A | |
| SCHEMBL5835735 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2MAPK10ALDH1A1NPC1RAB9A | |
| SCHEMBL5835745 | 0.80 | MAPT (0.50) | SMN1; SMN2MAPK10ALDH1A1GAALMNA | |
| SCHEMBL7936040 | 0.80 | ALOX15 (0.52) | SMN1; SMN2MAPK10ALDH1A1NPC1RAB9A | |
| SCHEMBL5839769 | 0.80 | ALOX15 (0.49) | SMN1; SMN2MAPK10ALDH1A1NPC1RAB9A | |
| SCHEMBL29003794 | 0.79 | MAPT (0.55) | SMN1; SMN2ALDH1A1GAALMNA | |
| SCHEMBL5835819 | 0.78 | CDK2 (0.63) | SMN1; SMN2MAPK10ALDH1A1RAB9ALMNA | |
| SCHEMBL27481150 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK10ALDH1A1RAB9ALMNA | |
| SCHEMBL966406 | 0.78 | ALOX15 (0.53) | LMNAFFAR2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |