Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7936040 | 0.83 | ALOX15 (0.52) | ALOX15FFAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27545748 | 0.80 | ALOX15 (0.53) | ALOX15FFAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5837008 | 0.80 | SMN1; SMN2 (0.56) | ALOX15FFAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL21578016 | 0.79 | KDM4E (0.60) | ALOX15FFAR2MEN1KMT2AALDH1A1 | |
| SCHEMBL16086080 | 0.78 | ALOX15 (0.54) | ALOX15FFAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL966406 | 0.77 | ALOX15 (0.53) | ALOX15FFAR2LMNAMAPTMEN1 | |
| SCHEMBL5835745 | 0.76 | MAPT (0.50) | ALOX15FFAR2SMN1; SMN2LMNAMAPT | |
| SCHEMBL21533493 | 0.74 | ALDH1A1 (0.62) | LMNAALDH1A1 | |
| SCHEMBL28089066 | 0.74 | FFAR2 (0.50) | ALOX15FFAR2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6279225 | 0.72 | FFAR2 (0.49) | ALOX15FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |