Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10253052 | 0.89 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9AMAPK10PKM | |
| SCHEMBL6361249 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL17368178 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL14903117 | 0.85 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL28413462 | 0.83 | ALDH1A1 (0.61) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL28417860 | 0.83 | NPC1 (0.54) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL15947692 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AGAATP53 | |
| SCHEMBL5835735 | 0.82 | SMN1; SMN2 (0.83) | SMN1; SMN2NPC1RAB9AMAPK10ALDH1A1 | |
| SCHEMBL5837008 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AGAAMAPK10 | |
| SCHEMBL7924409 | 0.81 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9ATP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |