Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPRB | P23467 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315778 | 0.88 | PTPN2 (0.38) | CXCR2PTPN2PTPN1PTPRBALDH1A1 | |
| SCHEMBL5841311 | 0.86 | CTSS (0.32) | CXCR2ALDH1A1HPGDPOLBCTSS | |
| SCHEMBL5838379 | 0.86 | CTSS (0.32) | CXCR2ALDH1A1HPGDPOLBCTSS | |
| SCHEMBL5838437 | 0.83 | CTSS (0.38) | CXCR2PTPN2PTPN1PTPRBCTSS | |
| SCHEMBL5842479 | 0.82 | PTPN1 (0.45) | PTPN2PTPN1PTPRBPOLB | |
| SCHEMBL5837519 | 0.82 | PTPN1 (0.45) | PTPN2PTPN1PTPRBPOLB | |
| SCHEMBL5837475 | 0.81 | PTPN1 (0.40) | CXCR2PTPN2PTPN1PTPRBALDH1A1 | |
| SCHEMBL5838593 | 0.80 | PTPN2 (0.39) | CXCR2PTPN2PTPN1PTPRBALDH1A1 | |
| SCHEMBL5838097 | 0.80 | CTSS (0.45) | CXCR2CTSSCTSK | |
| SCHEMBL5837704 | 0.76 | CXCR2 (0.39) | CXCR2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |