Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838379 | 1.00 | CTSS (0.32) | CTSSCTSKPOLBMEN1KMT2A | |
| SCHEMBL6317021 | 0.87 | ADORA1 (0.35) | POLBMEN1KMT2ACXCR2ADORA1 | |
| SCHEMBL5837100 | 0.86 | CXCR2 (0.36) | CTSSCTSKPOLBCXCR2ALDH1A1 | |
| SCHEMBL5837074 | 0.78 | ADORA1 (0.49) | CTSSCTSKMEN1KMT2AATM | |
| SCHEMBL5841346 | 0.78 | CXCR2 (0.30) | CXCR2 | |
| SCHEMBL5838672 | 0.78 | ADORA1 (0.38) | POLBMEN1KMT2ACXCR2ADORA1 | |
| SCHEMBL5838350 | 0.78 | ADORA1 (0.38) | POLBMEN1KMT2ACXCR2ADORA1 | |
| SCHEMBL5837645 | 0.78 | ADORA1 (0.34) | POLBMEN1KMT2AADORA1ALDH1A1 | |
| SCHEMBL5837519 | 0.75 | PTPN1 (0.45) | POLB | |
| SCHEMBL5842479 | 0.75 | PTPN1 (0.45) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |